Key Topic – Page 3

The protective effects of dietary polyphenols in human health and disease

Primary Supervisor: A/Prof Abi Santhakumar
Location: Wagga Wagga
Keywords: polyphenols, haematology, antioxidants, food, nutrition, phenolic extracts, cardiovascular disease, diabetes
Research Group: Food as Medicine (FAM) Research Group

Synopsis:
This research project explores the role of dietary polyphenols in promoting human health and preventing disease. Polyphenols, naturally occurring antioxidants found in plant-based foods, have demonstrated potential in mitigating oxidative stress, inflammation, and metabolic dysfunction. This study will investigate their protective effects on key health outcomes, including cardiovascular disease and diabetes, using a combination of in vitro, ex vivo, and in vivo experimental approaches.

Under the supervision of A/Prof Abi Santhakumar, this research aligns with the Food as Medicine (FAM) Research Group, focusing on the intersection of nutrition, haematology, and chronic disease prevention. The project will assess the bioavailability, mechanisms of action, and therapeutic potential of polyphenol-rich foods and phenolic extracts.

Researchers will have access to state-of-the-art facilities across Wagga Wagga and all campuses to conduct multidisciplinary investigations. This project is ideal for candidates interested in antioxidants, haematology, medical laboratory science, and clinical nutrition.

Interested? Start the conversation here by contacting A/Prof Abi Santhakumar

Evaluating Natural Product-Based Modulators for Cancer Therapy Using the Tumour-Induced Chicken-Egg Model

Primary Supervisor: Dr Ken Chinkwo
Location: Wagga Wagga
Keywords: cancer, chicken-egg, CAM assay, sorghum, antioxidants
Research Group: Food as Medicine (FAM) Research Group

Synopsis:

This project, led by Dr. Kenneth Chinkwo at Charles Sturt University, aims to revolutionize cancer study by developing a novel, cost-effective preclinical model using the Chicken Chorioallantoic Membrane (CAM) assay. By engrafting cancer cells such as colon, prostate, as well as canine osteosarcoma (OSA) cell lines onto the CAM, the research seeks to evaluate the therapeutic potential of polyphenolic compounds derived from sorghum and chickpeas, known for their potent antioxidant and anticancer properties.

This innovative approach addresses significant gaps in most cancers, including OSA treatments, but also offers a translational bridge to human oncology, as canine osteosarcoma closely mirrors its human counterpart. The project promises to provide foundational insights into tumor biology, angiogenesis, and metastasis while exploring natural therapeutic solutions with minimal toxicity. With a focus on reproducibility, ethical considerations, and real-time monitoring, this research has the potential to significantly advance both veterinary and human cancer treatment strategies, making it an exciting opportunity for students interested in cutting-edge cancer research and translational medicine.

ASBMB Biomolecular Horizon 2024 Poster

Interested? Start the conversation here by contacting Dr Kenneth Chinkwo

A qualitative study to explore the lived experience of people with hEDS and HSD on tertiary education and the impacts on career advancement.

Primary Supervisor: Dr Boris Budiono
Location: All campuses/Online
Keywords: ehlers-danlos syndrome, qualitative resesarch, disability research, focus groups, tertiary education

People with hypermobile Ehlers-Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) experience barriers to full participation in society due to the significant emotional and physical sequalae of their condition. To date, no studies have examined people with hEDS/HSD’s participation in university education. However, investigations into the lived experience of hEDS/HSD and the academic adjustments needed by people with disability in a university education setting suggest that the university education environment may present unique challenges for people with hEDS/HSD such as lack of professional understanding, social stigma, and the experience of physical and mental restrictions.

This qualitative research project will investigate the perspectives and experiences when accessing and engaging in university education experienced by people with hEDS/HSD. Focus groups will be used to obtain rich data about interactions between the individual, social, physical, and organisational factors that influence the person with hEDS/HSD experience of university education. Reflexive thematic analysis of focus group data will seek to identify the dominant perspectives and experiences of people with hEDS/HDS as the move through the university education system from enrolment to graduation.

Interested? Start the conversation here by contacting Dr Boris Budiono

The development of rapid diagnostic testing for disease management using CRISPR

Primary Supervisor: Dr Martin Pal
Location: Wagga Wagga, All campuses
Keywords: point-of-care diagnostic assays, CRISPR, agriculture, disease management

Rapid and reliable testing for pathogens is paramount for disease management or agricultural applications in the context of biosecurity. In this regard, field-based or point-of-care diagnostic assays circumvent the need for skilled personnel and specialised laboratory equipment. Honours research opportunities are available to exploit the use of CRISPR-associated nucleases (Cas proteins) for rapid and precise detection of nucleic acids of potential pathogens.

Interested? Start the conversation here by contacting Dr Martin Pal

Early detection and intervention of neurodegenerative disorders

Primary Supervisor: Dr Shaoyu (Shaun) Wang
Location: Orange/Flexible
Keywords: neuroscience, neurodegenerative disorders, early detection, intervention
Research Group: Ageing Well Research Group

Synopsis:
A major interest of my research group is to detect the earliest possible changes from normal ageing processes towards the neurodegenerative diseases. My group developed a precursor hypothesis: In the progression of the (brain) ageing to neurodegenerative disorders, there exists a precursor state/window. The pathological changes occurring in this window is reversible, thus providing an opportunity to intervene or stop this pathological progression. The diminishing cognitive reserve is seen as a basic property of the precursor state.

Aims: to assess the cognitive reserves of rural populations residing in regional and rural NSW. We hypothesise that there is a wide range of cognitive reserves across different age groups and between individuals of the same age group. We will use tools/instruments to measure cognitive reserves in a cross-sectional design. We anticipate that the findings of the project will shed light on how the modifiable factors and demographic characteristics of the population are associated with cognitive reserves.

Interested? Start the conversation here by contacting Dr Shaoyu (Shaun) Wang

Cultural and Psychological Aspects of Consent in Medical Imaging

Primary Supervisor: Mr Shayne Chau
Location: All campuses/Online
Keywords: Cultural Psychology, Informed Consent, Medical Imaging, Patient Experience, Health Communication
Type of Project: Mixed-Methods Research (Quantitative and Qualitative)
Study Availability: Available until December 2026

Synopsis:
This mixed-methods project explores how cultural and psychological factors shape patient experiences and decision-making during the informed consent process in medical imaging. It investigates the influence of cultural beliefs, health literacy, trust in healthcare providers, and psychological responses such as anxiety (“scanxiety”) on patient understanding and participation. By identifying barriers and facilitators in the consent process, the study aims to develop recommendations for culturally sensitive and patient-centered consent practices in radiography.
URL link to relevant journal articles or website: 10.1016/j.soncn.2023.151502

Interested? Start the conversation here by contacting Mr Shayne Chau

Exploring the anticancer potential of cereal and pulse phenolic extracts

Primary Supervisor: Dr Ken Chinkwo
Location: Wagga Wagga
Keywords: cancer, chicken-egg, CAM assay, sorghum, antioxidants
Research Group: Food as Medicine (FAM) Research Group

Synopsis:

Our study examines the anticancer properties of cereals and pulses, particularly focusing on the effects of phenolic extracts from sorghum, rice,
barley, oats, and chickpeas on SW480 and HT29 cancer cell lines. It highlights significant findings, such as the ability of these extracts to reduce cancer cellproliferation and promote apoptosis through the modulation of tumour suppressors and other genes. Additionally, it showcases the potential of these dietary compounds to inhibit cancer cell migration, indicating their broader health-promoting properties.

The research also outlines ongoing work, including a pilot project employing an in ovo tumor model to further explore the extract’s anticancer mechanisms, signalling a promising direction for future investigations into cereal and pulse bioactivity as potential therapeutic agents against cancer.

Link to research poster.

Interested? Start the conversation here by contacting Dr Kenneth Chinkwo

Burnout and Resilience in Radiography Professionals and Students: A Systematic Review of Psychological Well-being and Coping Strategies

Primary Supervisor: Mr Shayne Chau
Location: All campuses/Online
Keywords: systematic review, Burnout, Resilience, Radiography, Coping Strategies, Psychological Well-being
Study Availability: Available until December 2026

Synopsis:
This systematic review aims to synthesize existing literature on burnout, resilience, and coping strategies among radiography professionals and students. The review will explore the prevalence of burnout, identify contributing factors, and evaluate the effectiveness of resilience-building interventions. It will focus on psychological well-being, the impact of clinical environments, and the role of education and institutional support in promoting coping strategies. The findings will offer evidence-based recommendation for improving mental health and well-being in radiography education and practice.

Interested? Start the conversation here by contacting Mr Shayne Chau

A Systematic Review of Exercise/Diet in managing symptoms in people with hEDS

Primary Supervisor: Dr Boris Budiono
Location: All campuses/Online
Keywords: systematic review, ehlers-danlos syndrome, exercise, diet

Genetic connective tissue disorders such as hypermobile Ehlers Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) are historically difficult to treat due to the lack of understanding in the medical community. This means that it lacks objective diagnostic criteria, and clear treatment or management options. Besides physical exercise, one aspect that is purportedly beneficial to patients is nutrition and dietary supplementation. For example, many patients anecdotally report a gluten-free, FODMAP or avoidance of certain food groups reduce debilitating symptoms. Our research group’s work has shown that 59% patients self-reported food allergies/sensitivities in a 2021 national survey. Furthermore, some report the use of specific supplements that may be of benefit. This project aims to review the current scientific literature in the area, as it is possible that much of the information is anecdotal in nature.

Interested? Start the conversation here by contacting Dr Boris Budiono