Early detection and intervention of neurodegenerative disorders

Primary Supervisor: Dr Shaoyu (Shaun) Wang
Location: Orange/Flexible
Keywords: neuroscience, neurodegenerative disorders, early detection, intervention
Research Group: Ageing Well Research Group

Synopsis:
A major interest of my research group is to detect the earliest possible changes from normal ageing processes towards the neurodegenerative diseases. My group developed a precursor hypothesis: In the progression of the (brain) ageing to neurodegenerative disorders, there exists a precursor state/window. The pathological changes occurring in this window is reversible, thus providing an opportunity to intervene or stop this pathological progression. The diminishing cognitive reserve is seen as a basic property of the precursor state.

Aims: to assess the cognitive reserves of rural populations residing in regional and rural NSW. We hypothesise that there is a wide range of cognitive reserves across different age groups and between individuals of the same age group. We will use tools/instruments to measure cognitive reserves in a cross-sectional design. We anticipate that the findings of the project will shed light on how the modifiable factors and demographic characteristics of the population are associated with cognitive reserves.

Interested? Start the conversation here by contacting Dr Shaoyu (Shaun) Wang

Exploring the anticancer potential of cereal and pulse phenolic extracts

Primary Supervisor: Dr Ken Chinkwo
Location: Wagga Wagga
Keywords: cancer, chicken-egg, CAM assay, sorghum, antioxidants
Research Group: Food as Medicine (FAM) Research Group

Synopsis:

Our study examines the anticancer properties of cereals and pulses, particularly focusing on the effects of phenolic extracts from sorghum, rice,
barley, oats, and chickpeas on SW480 and HT29 cancer cell lines. It highlights significant findings, such as the ability of these extracts to reduce cancer cellproliferation and promote apoptosis through the modulation of tumour suppressors and other genes. Additionally, it showcases the potential of these dietary compounds to inhibit cancer cell migration, indicating their broader health-promoting properties.

The research also outlines ongoing work, including a pilot project employing an in ovo tumor model to further explore the extract’s anticancer mechanisms, signalling a promising direction for future investigations into cereal and pulse bioactivity as potential therapeutic agents against cancer.

Link to research poster.

Interested? Start the conversation here by contacting Dr Kenneth Chinkwo

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