Synthesis and Biological Evaluation of Cyclic Peptides

Primary Supervisor: Dr David Leaver 
Co-supervisors: Dr. Doaa Hanafy
Location: Wagga Wagga
Keywords: Infectious diseases, peptides, enzymes
Study Availability: Available until December 2027
Research Group: Medical Sciences

Synopsis:
Opportunistic pathogens in humans cause millions of deaths each year and there is an urgent need to find new drugs right now! Macrocyclic peptides were chosen for this project as they bind to their molecular targets with high affinity and selectivity, while exhibiting greater proteolytic stability and membrane permeability in comparison to their linear counterparts. Cyclic peptides designed and synthesized in this project will be screened against enzyme targets in order to discover novel antimicrobial drugs.  

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Interested? Start the conversation here by contacting Dr David Leaver 

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