Primary Supervisor: Dr Boris Budiono
Location: All campuses
Keywords: ehlers-danlos syndrome, inflammation, mast cell activation, syndrome, POTS, fibromyalgia
Research Group: Food as Medicine (FAM) Research Group
Mast Cell Activation Syndrome (MCAS) is a condition where mast cells inappropriately and excessively release chemical mediators, namely histamine, that result in inflammatory responses and symptoms such as hives or flushing, to anaphylaxis. This project aims to determine the linkages between three distinct syndromes (MCAS, Postural Orthostatic Tachycardia (POTS), and fibromyalgia) that are commonly found in certain individuals with connective tissue disorder, hypermobile Ehlers Danlos Syndrome (hEDS). We will investigate the literature to find current evidence of linkage, and to determine future directions in research in an evidence-based manner.
Interested? Start the conversation here by contacting Dr Boris Budiono
I have been diagnosed with hEds, POTS and Fibromyalgia. I am going in too see my doctor in January and seek treatment for possible MCAS. I truly believe I have this as well. This article came up in my research and would like to know if there are any follow ups to it?
Hi Jennifer,
Thank you for taking the time to comment here. All the best with your doctor’s appointment.
Indeed there is increasing evidence that MCAS and hEDS share co-morbidities.. we’ve had some research project level work done so far at CSU, but are hoping to publish soon.
As for other papers, here are a few that may be of interest:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9022617/
https://gptoolkit.ehlers-danlos.org/wp-content/uploads/2021/11/5-Mast-cell-section-my-book-for-RCGP-Toolkit-LHedit.pdf
Apologies if you have these already!
Boris