Primary Supervisor: Dr. Nidhish Francis
Location: Wagga Wagga
Keywords: diabetes, polyphenols, cell culture, oxidative stress
Research Group: Food As Medicine (FAM) research group
Synopsis: This research project focuses on investigating plant-derived bioactive compounds, particularly polyphenols, as potential therapeutic agents for diabetes management. Diabetes, a chronic metabolic disorder characterised by impaired glucose metabolism and insulin resistance, affects millions worldwide. Current pharmacological treatments primarily manage symptoms but fail to address underlying mechanisms or prevent disease progression. This project aims to explore the potential of plant-derived polyphenols to regulate key pathways involved in diabetes development and progression.
Polyphenols, naturally occurring antioxidants found in plant-based foods, have shown promise in mitigating oxidative stress, inflammation, and insulin resistance—key contributors to diabetes pathology. This study will utilise advanced in vitro cell culture models to evaluate the effects of polyphenols on glucose uptake, insulin signalling, and oxidative stress markers. Molecular techniques such as RT-PCR and Western blot analysis will be employed to investigate the modulation of genes and proteins involved in glucose metabolism and inflammatory pathways. The findings aim to contribute to the development of natural, plant-based strategies for diabetes management, offering a complementary approach to conventional therapies. This project is ideal for candidates passionate about medical science, clinical nutrition, and exploring innovative solutions for diabetes care.
URL link to relevant journal articles or website: https://scholar.google.com.au/citations?hl=en&user=o6d7fCMAAAAJ
Interested? Start the conversation here by contacting Dr. Nidhish Francis